Iqbal Sayeed Selected Research

Progesterone

10/2021	Response to Korley et al.: Progesterone Treatment Does Not Decrease Serum Levels of Biomarkers of Glial and Neuronal Cell Injury in Moderate and Severe TBI Subjects: A Secondary Analysis of the Progesterone for Traumatic Brain Injury, Experimental Clinical Treatment (ProTECT) III Trial (DOI: 10.1089/neu.2020.7072).
5/2020	Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury.
1/2019	Repurposing and repositioning neurosteroids in the treatment of traumatic brain injury: A report from the trenches.
1/2019	Is a combination of progesterone and chloroquine more effective than either alone in the treatment of cerebral ischemic injury?
1/2019	Development of a novel progesterone analog in the treatment of traumatic brain injury.
2/2018	Effect of Progesterone on Cerebral Vasospasm and Neurobehavioral Outcomes in a Rodent Model of Subarachnoid Hemorrhage.
11/2017	Stress primes microglial polarization after global ischemia: Therapeutic potential of progesterone.
1/2017	On the Limitations of Progesterone Treatment in Very Severe Traumatic Brain Injury: What Can Be Learned from Allitt et al., "Progesterone Exacerbates Short-Term Effects of Traumatic Brain Injury".
1/2017	Suboptimal Dosing Parameters as Possible Factors in the Negative Phase III Clinical Trials of Progesterone for Traumatic Brain Injury.
1/2017	Intralipid Vehicle Does Not Interfere with the Efficacy of Progesterone in Attenuating Edema following Traumatic Brain Injury.

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Iqbal Sayeed Research Topics

Disease

22	Traumatic Brain Injuries (Traumatic Brain Injury) 10/2021 - 04/2006
18	Stroke (Strokes) 01/2019 - 05/2004
16	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2019 - 04/2006
15	Brain Injuries (Brain Injury) 05/2020 - 01/2007
14	Infarction (Infarctions) 01/2019 - 05/2004
14	Ischemic Stroke 01/2019 - 04/2006
10	Ischemia 05/2020 - 05/2004
9	Inflammation (Inflammations) 05/2020 - 01/2009
8	Brain Ischemia (Cerebral Ischemia) 05/2020 - 05/2004
8	Body Weight (Weight, Body) 01/2016 - 01/2002
4	Hypoxia (Hypoxemia) 09/2015 - 01/2014
3	Edema (Dropsy) 01/2017 - 04/2006
3	Cerebral Infarction 03/2015 - 01/2007
3	Contusions 08/2013 - 04/2006
3	Wounds and Injuries (Trauma) 01/2011 - 04/2006
3	Parkinson Disease (Parkinson's Disease) 03/2006 - 02/2003
2	Neuroinflammatory Diseases 01/2020 - 09/2015
2	Perceptual Disorders (Hemispatial Neglect) 05/2016 - 02/2014
2	Reperfusion Injury 03/2015 - 02/2013
2	Brain Infarction 09/2014 - 02/2014
2	Necrosis 10/2009 - 01/2009
2	Brain Edema (Cerebral Edema) 10/2009 - 04/2006
2	Parkinsonian Disorders (Parkinsonism) 10/2003 - 02/2003
1	COVID-19 related pediatric multisystem inflammatory disease 01/2022
1	COVID-19 01/2022
1	Craniocerebral Trauma (Head Injury) 12/2020
1	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 02/2018
1	Intracranial Vasospasm 02/2018
1	Transient Ischemic Attack 01/2016
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 09/2015
1	Carotid Stenosis (Carotid Artery Stenosis) 07/2015
1	Thrombosis (Thrombus) 07/2015
1	Cognitive Dysfunction 07/2015
1	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 07/2015
1	Spinal Cord Injuries (Spinal Cord Injury) 05/2015
1	Ischemic Optic Neuropathy (Anterior Ischemic Optic Neuropathy) 05/2015
1	Vascular Diseases (Vascular Disease) 01/2015

Drug/Important Bio-Agent (IBA)

42	Progesterone FDA LinkGeneric 10/2021 - 04/2006
13	Neuroprotective AgentsIBA 11/2017 - 03/2006
9	Hormones (Hormone)IBA 01/2019 - 07/2009
7	Vitamin D FDA LinkGeneric 01/2019 - 07/2009
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 02/2014
5	salicylhydroxamic acid (SHAM)IBA 11/2017 - 01/2011
4	NeurosteroidsIBA 01/2019 - 04/2006
4	CytokinesIBA 11/2017 - 01/2009
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2016 - 09/2011
4	Pregnanolone (Allopregnanolone)IBA 11/2010 - 04/2006
4	AntioxidantsIBA 01/2009 - 02/2003
4	Sodium SeleniteIBA 01/2005 - 01/2002
3	OsteopontinIBA 01/2022 - 01/2020
3	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2014
3	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2019 - 01/2014
3	Matrix Metalloproteinases (MMPs)IBA 01/2014 - 11/2010
2	LipidsIBA 01/2017 - 01/2002
2	Glial Fibrillary Acidic ProteinIBA 05/2016 - 02/2014
2	NF-kappa B (NF-kB)IBA 01/2015 - 12/2009
2	Tissue Plasminogen Activator (Alteplase)FDA Link 02/2014 - 01/2014
2	cresyl violetIBA 02/2014 - 11/2010
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 04/2013 - 07/2010
2	Caspase 3 (Caspase-3)IBA 09/2011 - 05/2004
2	GangliosidesIBA 01/2004 - 01/2002
2	Phospholipids (Phosphatides)FDA LinkGeneric 01/2004 - 01/2002
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2004 - 01/2002
2	CholesterolIBA 01/2004 - 01/2002
2	thiobarbituric acidIBA 01/2004 - 01/2002
2	Thiobarbituric Acid Reactive SubstancesIBA 01/2004 - 01/2002
2	Oxidopamine (6 Hydroxydopamine)IBA 10/2003 - 02/2003
2	Oxidants (Oxidizing Agents)IBA 10/2003 - 02/2003
1	C-Reactive ProteinIBA 01/2022
1	Interleukin-6 (Interleukin 6)IBA 01/2022
1	Ferritins (Ferritin)IBA 01/2022
1	HMGB1 Protein (HMG1)IBA 05/2020
1	SteroidsIBA 05/2020
1	NLR ProteinsIBA 05/2020
1	InflammasomesIBA 05/2020
1	Immunoglobulins (Immunoglobulin)IBA 01/2019
1	Chloroquine (Aralen)FDA LinkGeneric 01/2019
1	Immunoglobulin G (IgG)IBA 01/2019
1	Nerve Growth Factors (Neurotrophins)IBA 11/2017
1	EmulsionsIBA 01/2017
1	phospholipid emulsion soybean oil (Intralipid)IBA 01/2017
1	Progesterone Receptors (Progesterone Receptor)IBA 11/2016
1	Superoxides (Superoxide)IBA 01/2016
1	Toll-Like Receptors (Toll-Like Receptor)IBA 09/2015
1	EdaravoneIBA 07/2015
1	Free Radical ScavengersIBA 07/2015
1	Protein Kinases (Protein Kinase)IBA 03/2015
1	ethyl 6- (N- (2- chloro- 4- fluorophenyl)sulfamoyl)cyclohex- 1- ene- 1- carboxylateIBA 03/2015
1	Toll-Like Receptor 4IBA 03/2015
1	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2015
1	Calcitriol (Calcijex)FDA LinkGeneric 01/2015
1	Tight Junction ProteinsIBA 01/2015
1	Retinaldehyde (Retinal)IBA 04/2014

Therapy/Procedure

4	Therapeutics 01/2019 - 01/2012
4	Injections 01/2016 - 04/2006
2	Intraperitoneal Injections 11/2017 - 01/2012
2	Subcutaneous Injections 11/2017 - 01/2014
2	Sutures (Suture) 01/2012 - 04/2006
1	Ligation 06/2015
1	Suture Techniques 04/2014